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Is Centella (Cica) safe, and who should be careful with it?

Centella asiatica (Cica) is generally very well tolerated, but it is classed as a weak sensitizer, so a few people should be careful. Anyone with a known allergy to Centella, or to plants in the carrot/celery family (Apiaceae/Umbelliferae), is best avoiding it, and anyone who has reacted to it before should patch-test first. Reported allergic reactions are uncommon and were mostly linked to prolonged use on already-compromised skin, sometimes alongside added fragrance, so fragrance-free Cica products are a safer pick for reactive skin. This is a cosmetic soothing ingredient for the look and comfort of skin, not a treatment for any skin condition.
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Related ingredients

Centella Asiatica (Cica / Gotu Kola / Tiger Grass)

Sources

  1. Allergic contact dermatitis due to Centella asiatica: a new case (PubMed 8766746) — explicitly describes Centella asiatica as 'a weak sensitizer'.
  2. CIR Safety Assessment of Centella asiatica-Derived Ingredients as Used in Cosmetics (Johnson W et al., Int J Toxicol 2023; CIR Expert Panel) — concluded safe as used in cosmetics; low reported leave-on use concentration (~0.5%); negative human patch tests at 1% and 5% in petrolatum.
This is cosmetic reference information, not medical advice.